Excellent response to adalimumab in a patient with Papillon–Lefèvre syndrome: A case report

Papillon–Lefèvre syndrome (PLS) is a rare autosomal recessive disease that presents clinically with palmoplantar keratoderma and periodontitis results in early-onset dental loss. PLS management difficult. We report 30-year-old female who had unfavourable response to topical keratolytic creams, oral isotretinoin narrow-band ultraviolet-B (NB-UVB) phototherapy but showed significant clinical improvement adalimumab.